Fig. 1

The expression of TSP-2 is correlated with MMP-2 expression and tumor stage in PCa. The THBS2 genes were searched from the GEO database. a GDS1439 and b GDS2545 were detected by microarray, and the TSP-2 expression values were collected independently. c TSP-2 and MMP-2 protein were determined in the tissue array by IHC staining using their specific antibodies. The sections were photographed, and staining intensity was then scored from 0 to 5 based on their expression intensity. The expression of TSP-2 (d) and MMP-2 (e) were quantified by the clinical pathologic stages (stage I and II for early stage, stage III and IV for late stage), and f the correlation between TSP-2 and MMP-2 were analyzed with Pearson correlation. The one-way ANOVA with Bonferroni’s multiple comparisons test was performed and p ≤ 0.05 showed significance. N normal, T tumor