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Table 1 Correlation between Klotho expression and clinical characteristics of DLBCL patients

From: Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

Characteristics No. of patients Klotho expression p value
Positive (%) Negative
Age (years)
 <60 27 4(14.8%) 23 0.857
 ≥60 23 3(13.0%) 20
Gender
 Male 26 2(7.7%) 24 0.181
 Female 24 5(20.8%) 19
Ann Arbor stage
 I or II 12 5(41.7%) 7 0.002
 III or IV 38 2(5.3%) 36
B symptoms
 Present 14 2(14.3%) 12 0.971
 Absent 36 5(13.9%) 31
Subtype
 GCB 15 2(13.3%) 13 0.929
 Non-GCB 35 5(14.3%) 30
Serum LDH
 Normal 35 5(14.3%) 30 0.929
 Elevated 15 2(13.3%) 13
Extranodal involvement
 Absent 28 4(14.3%) 18 0.45
 Present 22 3(13.7%) 25
IPI score
 0–2 35 6(17.1%) 29 0.328
 3–5 15 1(6.7%) 14
  1. LDH lactate dehydrogenase, IPI international prognostic index