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Table 1 Patient and graft characteristics

From: Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

Variable

Haploidentical N = 89

Matched related N = 69

P

Age (years), median (range)

22 (4–51)

33 (7–61)

<0.001

 Children, no. (%)

33 (37.1%)

7 (10.1%)

<0.001

 Adult, no. (%)

56 (62.9%)

62 (89.9%)

 

Male/female, no.

57/32

39/30

0.337

SAA/VSAA, no.

69/20

58/11

0.305

Disease course (months), median (range)

0.507

 Interval from SAA diagnosis to SCT

1.5 (1–4.0)

1.0 (1–3.0)

Previous transfusion

 Median units of RBC (range)

7.0 (0–30)

8.0 (2–34)

0.115

 Median units of PLT (range)

13.5 (0–90)

10.0 (2–90)

0.036

aECOG pre-SCT, median, (range)

1 (0–3)

1 (0–2)

0.568

Donor-patient sex match, no. (%)

0.042

 Male-male

40 (44.9%)

17 (24.6%)

 Male-female

19 (21.3%)

15 (21.7%)

 Female-male

19 (21.3%)

22 (31.9%)

 Female-female

11 (12.4%)

15 (21.7%)

Donor type, no. (%)

<0.001

 Sibling

25 (28.1%)

69 (100%)

 Parent

57 (64.0%)

–

 Child

5 (5.6%)

–

  bOthers

2 (2.2%)

–

HLA type, no (%)

<0.001

 6/6

4 (4.5%)

69 (100%)

 5/6

6 (6.7%)

–

 4/6

21 (23.6%)

–

 3/6

58 (65.2%)

–

ABO matched, no. (%)

0.414

 Matched

49 (55.1%)

44 (63.8%)

 Minor mismatched

18 (20.2%)

13 (18.8%)

 Major mismatched

14 (15.7%)

10 (14.5%)

 Different

8 (9.0%)

2 (2.9%)

Graft type, no. (%)

<0.001

 BM + PB

78 (87.6%)

43 (63.2%)

 BM only

9 (10.1%)

3 (4.4%)

 PB only

2 (2.2%)

22 (32.4%)

Median MNCs, ×10^8/kg (range)

9.9 (3.4–32.0)

10.5 (4.6–26.4)

0.817

Median CD34+ count, ×10^6/kg (range)

3.6 (0.5–18.8)

4.5 (1.5–30.2)

0.001

Median CD3+ count, ×10^8/kg (range)

1.8 (0.1–6.7)

2.1 (0.1–7.7)

0.530

Median CD4+ count, ×10^8/kg (range)

1.0 (0.1–3.5)

1.1 (0.1–5.0)

0.337

Median CD8+ count, ×10^8/kg (range)

0.7 (0.1–3.0)

0.8 (0.1–2.7)

0.147

Median follow-up among alive patients, mo. (range)

21.4 (7.1–47.6)

26.0 (7.5–47.6)

0.258

Neutrophil engraftment, median (range)

12 (9–20)

11 (8–19)

0.151

Platelet engraftment, median (range)

15 (6–91)

14 (7–36)

0.484

  1. BM bone marrow, PB peripheral blood, MNC mononuclear cell
  2. *Patient age, previous transfusion of platelet, donor-recipient sex match, graft type, and infused CD34 cells differed significantly between the two groups (P < 0.05). There were no other significances between group differences
  3. aECOG (Eastern Cooperative Oncology Group scale) is used to evaluate patients’ performance status
  4. bOther donor types were from cousins