Fig. 3

Effect of blocking DOT1L in the cell apoptosis and cell cycle. After exposure to 10 μM EPZ004777 and SGC0946 seperately for 12 days in both SK-OV-3 and TOV21G cells, cell apoptosis and cell cycle analyses in each group were determined by flow cytometry. a The typical images and b the proportion of apoptosis cell were measured in SK-OV-3 and TOV21G cells. The proportion of cell cycle distribution in SK-OV-3 cells (c) and in TOV21G cells (d) was shown. Columns are the mean of triplicate samples