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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Fig. 1

The Venn analysis show that caspase-1 gene regulatory effects have strong tissue specificities (direct comparison, non-meta-analysis). a Venn Diagram analysis of significantly changed genes among four different tissues comparing caspase-1 deletion to wild type. The logical relationships of caspase-1-regulated gene among four different tissues are shown in this diagram. 1Ts represent specific regulated genes in a single tissue (green arrow represent downregulated and red arrow represent upregulated), and 2Ts/3Ts/4Ts represent regulated genes in/among two/three/four involved tissues (−− represent mixed fold changes in involved tissues). b Heat map for fold changes of overlapped genes among four tissues. 1700112E06Rik, Lsm4, Pyhin1, and Tifa were all significantly downregulated by deletion of caspase-1 among four tissues. Nnt and Phka1 were significantly upregulated among the four tissues. And the other 14 genes were either upregulated or downregulated in analyzed tissues. c Venn diagram of significantly changed genes among three different intestinal tissues comparing caspase-1 deletion to WT. d Caspase-1 globally regulated gene expression are not ubiquitously regulated by two apoptosis pathways. e The major function of the six genes that are regulated by caspase-1 across all the four tissue types

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