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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Fig. 2

Cooperation analysis shows that among 163 genes that are highly regulated by caspase-1 and Sirt-1 in mouse adipose tissue, caspase-1 and Sirt-1 cooperatively regulates 142 genes (87.1%). a Explanation for the FC/FC plot. Plots distributed in II and IV quadrants represent caspase-1 independently regulated genes from Sirt-1. b Cooperation of Sirt-1 and caspase-1 in the adipose tissue. FC/FC plot comparing Log2 FC of genes for Sirt-1 KO vs. WT (x-axis) and parallel caspase-1 KO vs. WT (y-axis). Genes with significant expression changes (with fold changes no less than 2) were gated. Detailed information about these genes was shown in Additional file 1: Table S5. c The top five signatures of cooperation genes (p < 0.05) reversely regulated by caspase-1 and Sirt-1 in the adipose tissue. d The top five signatures of non-cooperation genes (p < 0.05) in the adipose tissue

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Journal of Hematology & Oncology

ISSN: 1756-8722

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