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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Fig. 4

Cooperation analysis shows that among 27 highly regulated genes by caspase-1 and IL-1β in mouse liver, Caspase-1 and IL-1β cooperatively regulated 7 genes (25.9%). a Explanation for the FC/FC plot. Plots distributed in quadrants II and IV represent genes that are regulated by caspase-1 independently of IL-1β. b Cooperation of IL-1β and caspase-1 in the liver. FC/FC plot comparing Log2 FC of genes for IL-1β treatment vs. control (x-axis) and parallel caspase-1 KO vs. WT (y-axis). c Represents significantly changed genes (fold change > 2) regulated by caspase-1 and IL-1β in Fig. 5b. d and e. The top five signatures of genes that are regulated by caspase-1 in cooperation with IL-1β in mouse liver (d). The top five signatures of the genes that are regulated by caspase-1 non-cooperatively with IL-1β (p < 0.05) in the liver

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