Fig. 7
Cooperation analysis shows that among the 7 caspase-1 and IL-1β globally regulated genes with >2 fold change, caspase-1 and IL-1β cooperatively regulate 6 genes (85.7%). a FC/FC plot comparing log2 transformed fold changes (Log2 FC) of genes for meta-Caspase-1 (deletion of Caspase-1 among six different tissues) vs. wild type (x-axis) and parallel meta-IL-1β (meta-analysis of treatment and transgenic IL-1β) vs. control (y-axis). b Significantly changed genes with fold changes higher than two among the four quadrants. c Further analysis by Ingenuity Pathway revealed the top five signatures of the genes regulated by caspase-1 with cooperation of IL-1β. d The top five signatures of the genes that are regulated by caspase-1 non-cooperatively with IL-1β (p < 0.05)