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Fig. 8 | Journal of Hematology & Oncology

Fig. 8

From: Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Fig. 8

Cooperation analysis shows that caspase-1 and IL-18 cooperatively regulated all of the four genes that had significant expression changes. a FC/FC plot comparing Log2 FC of genes for meta-caspase-1 (deletion of caspase-1 among six different tissues) vs. wild type (x-axis) and parallel IL-18 stimulation vs. control (y-axis). b Significantly changed genes with fold changes higher than two among the four quadrants. c/d The top five signatures of genes that are regulated by caspase-1 cooperatively with IL-18 and non-cooperatively (p < 0.05)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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