Fig. 2
From: Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia
Paradigm of integrated DNA methylation, genetic aberrations, and expression of AML leading to precise medicine. The integrated analysis of DNA methylation, genetic aberrations (gene fusions and mutations), and RNA expression (a) has revealed multiple AML subtypes, summarized into two groups (with or without recurrent genetic abnormalities) (b). Furthermore, each subtype will be characterized with distinct DNA methylation patterns (c), which play an important role in clinical implications (d), leading to precision medicine in AML. The clinical implications of DNA methylation are discussed more detail in the text