Fig. 3
From: XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy
Positron emission tomography (PET) and digital PCR plots from a biopsy specimen and plasma cell-free DNA from a classical Hodgkin lymphoma patient with mediastinal involvement. Representative views of digital PCR (dPCR) plots (mutant samples) for XPO1 E571K quantification in a tumor (VAF = 0.3%, left) and plasma cell-free DNA (cfDNA) (VAF = 0.15%, right) from a cHL patient at diagnosis by droplet dPCR (Biorad). Data are displayed in a scatter plot based on the color of FAM and VIC events. Green, blue, orange, and black plots represent wild-type alleles, mutant alleles, both alleles in the same droplet, or no amplifications, respectively. VAF, variant allele fraction