TY - JOUR AU - Ramalho-Carvalho, João AU - Graça, Inês AU - Gomez, Antonio AU - Oliveira, Jorge AU - Henrique, Rui AU - Esteller, Manel AU - Jerónimo, Carmen PY - 2017 DA - 2017/02/06 TI - Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer JO - Journal of Hematology & Oncology SP - 43 VL - 10 IS - 1 AB - Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent patterns, prompting us to investigate whether epigenetic repression of microRNAs expression might disrupt senescence in prostate cancer (PCa) cells. SN - 1756-8722 UR - https://doi.org/10.1186/s13045-017-0415-1 DO - 10.1186/s13045-017-0415-1 ID - Ramalho-Carvalho2017 ER -