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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

Fig. 5

miR-130b and miR-301b overexpression dramatically alters SASP expression in PC3 cells. a Comparing miR-130b or miR-301b overexpression with pre-miR-NC control, a global increase in mRNA levels of most SASP-related genes was depicted. This signature suggests that miR-130b or miR-301b-induced SASP reinforces senescence through autocrine mechanisms. b Comparison of miR-130b or miR-301b endogenous blockade with anti-miR-NC control revealed a decrease (e.g. MMP10) or minimal increase (e.g. IL1A) in mRNA expression of some genes. This suggests paracrine activity of SASP when miR-130b or miR-301b are inhibited in prostate cancer cells. All data are presented as mean of three independent experiments ± s.d. (*p < 0.05, **p < 0.01, ***p < 0.001)

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