Fig. 8

In vivo study and the schematic cartoon of the mechanism of circ-TTBK2. a The stable expressing cells were used for the in vivo study. The nude mice carrying tumors from respective groups were shown. The sample tumor from respective group was shown. b Tumor volume was calculated every 4 days after injection, and the tumor was excised after 44 days. ^* P < 0.05 vs. control group; ^# P < 0.05 vs. miR-217 (+) group; ^▲ P < 0.05 vs. circ-TTBK2 (−) group. The survival curves of nude mice injected into the right striatum (n = 15). P < 0.05 (miR-217 (+) or circ-TTBK2 (−) vs. control group); P < 0.01 (circ-TTBK2 (−)+miR-217 (+) group vs. control group). c The schematic cartoon of the mechanism of circ-TTBK2 as an oncogene negative regulation of miR-217 in glioma cells