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Fig. 8 | Journal of Hematology & Oncology

Fig. 8

From: Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1

Fig. 8

The biological and molecular roles of ERK3 in ICC. a ICC cells with lentiviral vector-mediated transfer of MAPK6 or GFP were assessed using a CCK-8 assay to evaluate the cell proliferation variation (* P < 0.05). (b) The mTORC1 status in ICC cells with lentiviral vector-mediated transfer of MAPK6 or GFP was detected by western blot. c CCLP-1 cells with lentiviral vector-mediated transfer of MAPK6 or GFP were implanted subcutaneously into the flank regions of nude mice. After 4 weeks, the mice were euthanized, and the tumors are shown. The expression of ERK3 in the xenografts was detected by IHC. d ERK3 was detected by IHC in tumors from 73 ICC patients after surgery. The relevance of the ERK3 expression level and the prognosis of ICC patients was evaluated by the Kaplan-Meier method

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