Extracellular vesicles-mediated noncoding RNAs transfer in cancer

Table 2 EV-associated lncRNAs in cancers

lncRNA	Cancer type	Biological function	Mechanism	Refs
lncRNA-p21	Prostate cancer	Suppress cancer initiation	Enhance drug resistance; suppress the genes regulated by p53	[71]
GAS5	Prostate cancer	Suppress cancer initiation	Suppress several anti-apoptotic genes	[72]
MEG3	Lung cancer	Suppress cancer initiation	Stimulate p53 expression	[73]
HOTAIR	Bladder cancer	Facilitate tumor progression	Regulate EMT and act as miR-205 sponge	[78]
MALAT1	Cervical cancer	Facilitate tumor progression	Modulate EMT	[79]
MONC	AKML	Facilitate tumor progression	Act as miR-99a/100~125b sponge	[81]
MIR100HG	AKML	Facilitate tumor progression	Same as lnc-MONC	[81]
H19	Liver cancer	Promote angiogenesis	Affect phenotype of endothelial cells	[86]
linc-ROR	HCC	Promote tumor progression	Inhibit p53 and act as miR-145 sponge	[88, 89]
linc-ROR	HCC	Enhance drug resistance	Elevate TGF level	[90]
Linc-VLDLR	HCC	Enhance drug resistance	Unknown	[67]
lncARSR	Renal cancer	Enhance drug resistance	Act as a ceRNA for miR-34 and miR-449	[91]

ISSN: 1756-8722