Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia

Table 1 Univariate and multivariate analysis for OS and RFS

	OS		RFS
	HR²	P value	HR²	P value
Univarite analysis (mut/all)
PTPN11 mut; positive vs negative in full cohort (8/117)	0.043	0.040	0.044	0.047
In B-ALL (7/92)	0.042	0.041	0.042	0.047
In Ph⁻B-ALL (7/54)	0.035	0.030	0.037	0.047
JAK2 Mut; positive vs negative in full cohort (7/117)	3.02	0.031	3.309	0.018
In B-ALL (5/92)	3.033	0.061	3.145	0.051
In Ph⁻B-ALL (5/54)	3.728	0.035	3.780	0.031
JAK1 mut; positive vs negative in Ph⁻B-ALL (4/54)	6.808	0.001	6.562	0.001
NOTCH1 and/or FBXW7 mut; positive vs negative
In T-ALL (12/25)	0.204	0.035	0.223	0.048
Multivariate analysis
PTPN11 mut; positive vs negative in full cohort	0.043	0.052	0.044	0.056
In B-ALL	0.042	0.063	0.042	0.056
In Ph⁻B-ALL	0.035	0.178	0.037	0.212
JAK2 mut; positive vs negative in full cohort	3.02	0.045	3.309	0.021
In Ph⁻B-ALL	3.728	0.049	3.780	0.044
JAK1 mut; positive vs negative in Ph⁻B-ALL	6.808	0.004	6.562	0.005
NOTCH1 and/or FBXW7 mut; positive vs negative
In T-ALL	0.204	0.055	0.223	0.069

ISSN: 1756-8722