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Table 1 miRNAs implicated in T-ALL biology

From: T-ALL and thymocytes: a message of noncoding RNAs

  miRBase release 21 Function Direct targets Refs
miR-19a hsa-miR-19a-3p ONC CYLD [120, 137]
ETP low
miR-19b hsa-miR-19b-3p ONC BIM, CYLD, PP2A, PRKAA1, PTEN [119121]
miR-20a hsa-miR-20a-5p ONC BIM, PHF6, PTEN [121]
miR-21 hsa-miR-21-5p ONC PDCD4 [101]
miR-26a hsa-miR-26a-5p ONC BIM, PHF6, PTEN [121]
miR-29 hsa-miR-29a-3p TSG HBP1 [129]
miR-30a hsa-miR-30a-5p/3p MYC repressed NOTCH1 [139, 140]
  Targets NOTCH1
miR-31 hsa-miR-31-5p TSG HBP1 [130]
miR-92 hsa-miR-92a-3p ONC BIM, FBXW7, IKZF1, NF1, PTEN [121]
miR-101 hsa-miR-101-3p Targets TAL1 TAL1 [142]
miR-128-3p hsa-miR-128-3p ONC PHF6 [99]
miR-140-5p hsa-miR-140-5p Targets TAL1 TAL1 [142]
miR-142-3p hsa-miR-142-3p ONC cAMP, GRα, PKA [125]
miR-146b-5p hsa-miR-146b-5p TAL1 repressed [123]
miR-149* hsa-miR-149-3p ONC JunB [126]
miR-150 hsa-miR-150-5p TSG MYB [130]
miR-155 hsa-miR-155-5p TSG HBP1, MYB [130]
miR-181a hsa-miR-181a-5p ONC EGR1, NRARP [128]
miR-193b-3p hsa-miR-193b-3p TSG MYB [131]
TAL-R low
miR-196a hsa-miR-196a-5p IMM high ERG [135]
miR-196b hsa-miR-196b-5p HOXA high ERG [134, 135]
IMM high
miR-200c hsa-miR-200c-3p TSG HBP1, MYB [130]
miR-204 hsa-miR-204-5p TSG SOX4 [132]
miR-221 hsa-miR-221-3p ETP high [137]
miR-222 hsa-miR-222-3p ETP high ETS1 [137]
miR-223 hsa-miR-223-3p ONC FBXW7 [121124, 136]
Myeloid high
TAL-R high
NOTCH1 activated
TAL1 activated
miR-363 hsa-miR-363-3p ETP low [137]
miR-448 hsa-miR-448 Targets TAL1 TAL1 [142]
miR-451 hsa-miR-451a NOTCH1 repressed c-MYC [138]
miR-485-5p hsa-miR-485-5p Targets TAL1 TAL1 [142]
miR-520d-5p hsa-miR-520d-5p Targets TAL1 TAL1 [142]
miR-590 hsa-miR-590-5p ONC RB1 [127]
miR-92 hsa-miR-92a-3p ONC BIM, FBXW7, IKZF1, NF1, PTEN [121]
  1. The most recent miRBase annotation was retrieved using the miRBase Tracker, www.mirbasetracker.org [160]
  2. ONC oncogenic miRNA, TSG tumor suppressor miRNA, ETP ETP-ALL, TAL-R TAL-rearranged T-ALL, IMM immature T-ALL, HOXA HOXA-overexpressing T-ALL