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Table 1 Biosensor kinetics and affinity measurements

From: Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

Clone name

k a (1/Ms)

k d (1/s)

t 1/2 (min)

K D (nM)

m15 Fab

2.1 × 106

1.4 × 10−3

8.3

0.67

PF-06747143 Fab

8.0 × 105

2.9 × 10−4

40

0.36

  1. Binding affinities of the Fab regions derived from PF-06747143 and its parent antibody m15 were measured by surface plasmon resonance
  2. k a kinetic association constant, k d kinetic dissociation constant, t 1/2 dissociation half-life, K D equilibrium dissociation constant
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Journal of Hematology & Oncology

ISSN: 1756-8722

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