Fig. 4
From: Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
19-H.28z T and 19.28z T cells have comparable antitumor efficacy in vivo. a Timeline and events of the experiment with intravenous NALM6-GL xenograft models. On day 0, 2 × 105 NALM6-GL cells were injected through the tail vein into the NSI mice, and on day 7, 2 × 106 GFP T, 19.28z T or 19-H.28z T cells were injected through the tail vein into each NALM6-GL-NSI mouse. The cell numbers refer to transduced CAR T cells. n = 3 for the GFP T cell group, and n = 4 for the 19.28z T and 19-H.28z T cell group. On day 7, 14, 22, and 33, bioluminescence imaging was conducted. b Survival analysis of mice treated with GFP T, 19.28z T, or 19-H.28z T cells. c Bioluminescence images of mice treated with GFP T, 19.28z T, or 19-H.28z T cells on day 7, 14, 22, and 33 post-infusion of 2 × 105 NALM6-GL cells