Skip to main content

Table 1 Criteria used for mutation filtering (variant inclusion)

From: Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort

Criterion name

Threshold value

General quality

 Phred-based quality

>50

 Strand bias

≤0.75

 Number of reads supporting called variant

≥10

Functional relevance

 Variant allelic frequency

≥5%

 Localization

Exonic and splice site

 Variant effect

Non-synonymous

SNP exclusion

 Variant allelic frequency

<95%

 Database annotation and alternative allelic frequency (1000 genomes project, European descendent samples)

Not listed in dbSNP v138 or listed, but MAF ≤0.01%

 Variants in detected in the control cohort of 23 non-tumoral samples from lymphoma patients

Not overlapping