- Twenty-seven cytokines/chemokines are investigated using the method we developed (Fig. 1b). We compared gene expression level in tumor tissues to adjacent normal tissues among six types of cancers in the digestive system, three types of cancers in the reproductive system, lung cancer, and lymphoma as shown. Genes with significant expression changes (p < 0.05) are shown here. Red text stands for upregulation (FC ≥ 2), and green text stands for downregulation (FC ≤ 0.5)