Fig. 3
From: The cell cycle checkpoint inhibitors in the treatment of leukemias
The DDR pathway in cancer cells. The high proliferation rate induced by different oncogenes (MYC or BCR-ABL1) can led to the so called replicative stress which is a negative signal for proliferation. In order to sustain the replicative stress and continue to proliferate, leukemic cells need to up-regulate different key elements of the DDR pathway, like CHK1. The two most important consequences of DDR elements up-regulation are (1) genetic instability due to the increment of tolerable level of DNA damages and (2) resistance to DNA damaging agents, such as chemotherapies, due to the up-regulation of the mechanisms involved in the DNA repair