Table 1 Tumor-associated antigens of CAR-T cell target
From: Chimeric antigen receptor T cells: a novel therapy for solid tumors
Antigen | Full name | Disease |
|---|---|---|
EGFR | Epidermal growth factor receptor | NSCLC, epithelial carcinoma, glioma |
EGFRvIII | Variant III of the epidermal growth factor receptor | Glioblastoma |
HER2 | Human epidermal growth factor receptor 2 | Ovarian cancer, breast cancer, glioblastoma, colon cancer, osteosarcoma, medulloblastoma |
MSLN | Mesothelin | Mesothelioma, ovarian cancer, pancreatic adenocarcinoma |
PSMA | Prostate-specific membrane antigen | Prostate cancer |
CEA | Carcinoembryonic antigen | Pancreatic adenocarcinoma, breast cancer, colorectal carcinoma |
GD2 | Disialoganglioside 2 | Neuroblastoma, melanoma |
IL13Rα2 | Interleukin-13Ra2 | Glioma |
GPC3 | Glypican-3 | Hepatocellular carcinoma |
CAIX | Carbonic anhydrase IX | Renal cell carcinoma (RCC) |
L1-CAM | L1 cell adhesion molecule | Neuroblastoma, melanoma, ovarian adenocarcinoma |
CA125 | Cancer antigen 125 (also known as MUC16) | Epithelial ovarian cancers |
CD133 | Cluster of differentiation 133 (also known as prominin-1) | Glioblastoma, cholangiocarcinoma (CCA) |
FAP | Fibroblast activation protein | Malignant pleural mesothelioma (MPM) |
CTAG1B | Cancer/testis antigen 1B (also known as NY-ESO-1) | Melanoma and ovarian cancer |
MUC1 | Mucin 1 | Seminal vesicle cancer |
FR-α | Folate receptor-α | Ovarian cancer |