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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: A novel lncRNA uc.134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1

Fig. 1

Aberrant expression of lncRNA uc.134 in HCC. a Hierarchical clustering analysis of lncRNAs differentially expressed in HCCLM3 and MHCC97L HCC cells. Upregulated genes are highlighted in yellow, and downregulated genes are in blue. (fold changes >5; P < 0.05). b Transcript of uc.134. c PCR products from the 5′-RACE and 3′-RACE procedures as shown by agarose gel electrophoresis. d–e The expression of uc.134 was analyzed by qRT-PCR in HCC tissues and HCC cells. *P < 0.05; **P < 0.01; and ***P < 0.001. f qRT-PCR analysis of RNAs purified from nuclear (red) and cytosolic (black) compartments in Bel7402 cells. ***P < 0.001. g ISH assays of uc.134 expression in HCC paraffin specimens and adjacent nontumor tissues. ***P < 0.001. h The Kaplan–Meier method was used to assess the survival of patients with HCC, and the log-rank test was used to compare survival between the uc.134-low and lncRNAuc.134-high groups (n = 170)

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