Table 1 Antiproliferative activity of trabectedin and rucaparib in soft-tissue sarcoma cells
From: Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas
Cell line ID | Histology | TP53 status | IC50 Trabectedin (nM) | IC50 rucaparib (μM) | Genomic index | ERCC5 mRNA (relative expression level) | ERCC1 mRNA (relative expression level) | BRCA1 mRNA (relative expression level) |
|---|---|---|---|---|---|---|---|---|
IB114 | UPS | WT | 0.352 | 1.488 | 400 | + | + | |
IB115 | DDLPS | WT | 0.445 | 1.104 | 93 | + | − | |
IB111 | DDLPS | WT | 0.480 | 1.364 | 331 | + | + | ++++ |
IB133 | LMS | Mut | 2.64 | 58.08 | 328 | + | ++ | |
IB134 | LMS | Mut | 1.92 | 40.88 | 340 | ++ | + | |
IB136 | LMS | Mut | 1.1 | 31.35 | 520 | − | + | + |
IB112 | LMS | Mut | 0.984 | 29.5 | 392 | + | ||
IB128 | ExOS | WT | 0.546 | 12.036 | 40 | −−− | − | −− |
93T449 | WDLPS | WT | 0.869 | 19.2 | ND | ND | ND | ND |