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Table 1 Antiproliferative activity of trabectedin and rucaparib in soft-tissue sarcoma cells

From: Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas

Cell line ID Histology TP53 status IC50 Trabectedin (nM) IC50 rucaparib (μM) Genomic index ERCC5 mRNA (relative expression level) ERCC1 mRNA (relative expression level) BRCA1 mRNA (relative expression level)
IB114 UPS WT 0.352 1.488 400   + +
IB115 DDLPS WT 0.445 1.104 93   +
IB111 DDLPS WT 0.480 1.364 331 + + ++++
IB133 LMS Mut 2.64 58.08 328 + ++  
IB134 LMS Mut 1.92 40.88 340   ++ +
IB136 LMS Mut 1.1 31.35 520 + +
IB112 LMS Mut 0.984 29.5 392    +
IB128 ExOS WT 0.546 12.036 40 −−− −−
93T449 WDLPS WT 0.869 19.2 ND ND ND ND
  1. UPS undifferentiated pleomorphic sarcoma, DDLPS dedifferentiated liposarcomas, LMS leiomyosarcomas, ExOS extrakeletal osteosarcoma, WDLPS well-differentiated liposarcoma