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Table 1 Baseline SjS-related features and risk of development of solid and hematological cancer

From: Characterization and risk estimate of cancer in patients with primary Sjögren syndrome

Baseline features Values at diagnosis (n = 1300) Solid cancer (n = 70) Hematological cancer (n = 61)
Age at diagnosis 54.8 ± 15.4
Gender (male) 99 (7.6)
Ethnicity (white) 1246 (95.8) 0.41 [0.10–1.71] 0.99 [0.14–7.29]
Dry mouth 1299 (99.9)
Dry eye 1234 (94.9) 0.48 [0.19–1.20] 1.37 [0.33–5.63]
Altered ocular tests 1013/1156 (87.6) 1.29 [0.47–3.58] 5.38 [0.74–39.03]
Altered parotid scintigraphy 835/992 (84.2) 0.87 [0.41–1.86] 1.34 [0.53–3.41]
Positive salivary gland biopsy 497/629 (79) 0.92 [0.35–2.44] 1.01 [0.42–2.45]
Anemia (Hb < 110 g/L) 216/1297 (16.7) 1.05 [0.59–1.86] 2.07 [1.20–3.58]
Leukopenia (<4000/mm3) 227/1297 (17.5) 1.49 [0.87–2.55] 0.96 [0.50–1.86]
Thrombocytopenia (<150,000/mm3) 87/1297 (6.7) 1.18 [0.54–2.57] 1.17 [0.50–2.72]
Neutropenia (<1500/mm3) 137/1296 (10.6) 1.41 [0.74–2.71] 1.66 [0.83–3.32]
Lymphopenia (<1000/mm3) 141/1295 (10.9) 1.80 [0.96–3.35] 1.43 [0.71–2.86]
Antinuclear antibodies+ 1124/1295 (86.8) 0.95 [0.49–1.85] 1.05 [0.50–2.21]
Rheumatoid factor+ 583/1245 (46.8) 1.13 [0.71–1.82] 1.08 [0.65–1.80]
Anti-Ro/SS-A+ 981/1294 (75.8) 1.43 [0.81–2.53] 1.28 [0.70–2.36]
Anti-La/SS-B+ 626/1289 (48.6) 0.99 [0.62–1.60] 1.17 [0.69–1.97]
Monoclonal gammopathy 114/1018 (11.2) 1.94 [0.99–3.80] 2.13 [1.08–4.19]
Cryoglobulins+ 70/929 (7.5) 0.70 [0.25–1.94] 4.37 [2.32–8.22]
Low C3 levels (<0.82 g/L) 144/1233 (11.7) 0.59 [0.21–1.62] 2.07 [1.06–4.03]
Low C4 levels (<0.11 g/L) 163/1218 (13.4) 1.07 [0.51–2.24] 2.23 [1.17–4.26]
  1. Values are represented as HRs [95% CIs]
  2. Set in italics, statistically significant (p < 0.05) SS-related features associated with cancer in the univariate Cox proportional hazards regression analysis adjusted for age at diagnosis and gender
  3. SjS Sjögren syndrome
  4. †Adjusting variable
  5. ‡Statistically significant (p < 0.05) SS-related features associated with cancer in the multivariate Cox proportional hazards regression analysis adjusted for age at diagnosis and gender