Skip to main content

Table 2 Association between organ-by-organ baseline ESSDAI activity at diagnosis and the risk of development of solid and hematological cancer

From: Characterization and risk estimate of cancer in patients with primary Sjögren syndrome

Variables Values at diagnosis (n = 1295)a Solid cancer (n = 70) Hematological cancer (n = 61)
Baseline DAS
 Low 707 (54.6) REF REF
 Moderate 426 (32.9) 1.17 [0.71–1.92] 1.37 [0.73–2.58]
 High 162 (12.5) 0.66 [0.28–1.56] 4.34 [2.35–8.00]
ESSDAI domains†
 Constitutional 115 (8.9) 1.13 [0.48–2.62] 2.44 [1.23–4.87]
 Lymphadenopathy 89 (6.9) 0.39 [0.10–1.60] 8.03 [4.62–13.94]
 Glandular 179 (13.8) 0.35 [0.14–0.87] 3.04 [1.78–5.18]
 Articular 498 (38.5) 0.95 [0.58–1.56] 1.30 [0.78–2.18]
 Cutaneous 131 (10.1) 1.40 [0.70–2.83] 1.10 [0.47–2.57]
 Pulmonary 102 (7.9) 1.58 [0.71–3.48] 1.07 [0.38–2.99]
 Renal 23 (1.8) 1.21 [0.17–8.80]
 Muscular 15 (1.2) 1.57 [0.22–11.4]
 Peripheral nervous system 54 (4.2) 0.59 [0.14–2.45]
 Central nervous system 41 (3.2) 0.44 [0.06–3.22]
 Hematological 447 (34.5) 1.31 [0.81–2.10] 1.36 [0.81–2.26]
 Biological 681 (52.6) 1.32 [0.81–2.15] 2.12 [1.19–3.76]
  1. Values are represented as the HRs (95% CIs)
  2. Set in italics, statistically significant (p < 0.05) ESSDAI domains associated with cancer in the univariate Cox proportional hazards regression analysis adjusted for age at diagnosis and gender
  3. REF reference level, ESSDAI EULAR-Sjögren Syndrome Disease Activity Index, DAS disease activity states
  4. aIn 5 patients, there was not enough information to calculate the ESSDAI at diagnosis
  5. ‡Statistically significant (p < 0.05) ESSDAI domains associated with cancer in the multivariate Cox proportional hazards regression analysis adjusted for age at diagnosis and gender
  6. †Level of activity is recoded as no versus any type of activity (low/moderate/high) in the analysis