Table 3 Association between organ-by-organ baseline ESSDAI activity at diagnosis and the risk of development of the three main subtypes of hematological cancer
From: Characterization and risk estimate of cancer in patients with primary Sjögren syndrome
Variables | B-cell MALT (n = 27) | B-cell non-MALT (n = 19) | Non-B-cell neoplasms (n = 15) |
|---|---|---|---|
Dry eye | – | 0.90 [0.12–6.83] | 0.76 [0.10–5.94] |
Altered ocular tests | – | 1.33 [0.17–10.17] | – |
Altered parotid scintigraphy | – | 1.10 [0.25–4.86] | 0.49 [0.13–1.87] |
Positive salivary gland biopsy | 1.84 [0.42–8.04] | 0.37 [0.07–2.12] | 0.83 [0.17–3.98] |
Anemia (Hb < 110 g/L) | 0.89 [0.31–2.61] | 2.58 [1.01–6.58] | 4.02 [1.42–11.38] |
Leukopenia (<4000/mm3) | 0.51 [0.15–1.69] | 0.84 [0.24–2.89] | 2.54 [0.86–7.52] |
Thrombocytopenia (<150000/mm3) | 0.47 [0.06–3.48] | – | 4.85 [1.64–14.34] |
Neutropenia (<1500/mm3) | 1.24 [0.42–3.63] | 0.51 [0.07–3.92] | 5.86 [1.89–18.14] |
Lymphopenia (<1000/mm3) | 2.12 [0.79–5.68] | 0.32 [0.04–2.48] | 2.14 [0.65–7.02] |
Antinuclear antibodies+ | 1.15 [0.35–3.84] | 0.86 [0.25–2.97] | 1.14 [0.26–5.10] |
Rheumatoid factor+ | 0.94 [0.43–2.03] | 1.16 [0.47–2.86] | 1.28 [0.46–3.53] |
Anti-Ro/SS-A+ | 1.07 [0.42–2.71] | 1.63 [0.53–5.03] | 1.26 [0.39–4.09] |
Anti-La/SS-B+ | 0.66 [0.30–1.46] | 2.35 [0.88–6.32] | 1.34 [0.47–3.83] |
Monoclonal gammopathy | 1.30 [0.38–4.43] | 3.34 [1.14–9.83] | 2.16 [0.58–8.04] |
Cryoglobulins+ | 6.32 [2.47–16.15] | 3.31 [1.06–10.36] | 4.36 [1.12–16.99] |
Low C3 levels (<0.82 g/L) | 3.25 [1.33–7.93] | 1.14 [0.26–5.06] | 1.43 [0.31–6.48] |
Low C4 levels (<0.11 g/L) | 1.76 [0.65–4.78] | 3.83 [1.31–11.21] | 1.36 [0.30–6.11] |
Baseline ESSDAI | 1.07 [1.03–1.11] | 1.04 [0.98–1.09] | 1.08 [1.03–1.13] |
Baseline DAS (REF = low) | |||
Moderate | 0.91 [0.33–2.51] | 1.20 [0.42–3.47] | 3.37 [0.84–13.52] |
High | 4.80 [1.99–11.62] | 2.60 [0.84–8.07] | 8.29 [2.05–33.55] |
ESSDAI domains† | |||
Constitutional | 1.31 [0.39–4.44] | 1.62 [0.37–7.12] | 7.20 [2.43–21.32] |
Lymphadenopathy | 9.39 [4.20–21.02] | 8.99 [3.35–24.14] | 4.74 [1.32–17.02] |
Glandular | 7.35 [3.36–16.10] | 1.34 [0.44–4.13] | 1.38 [0.38–5.04] |
Articular | 1.09 [0.50–2.39] | 2.07 [0.82–5.18] | 1.00 [0.34–3.00] |
Cutaneous | 1.16 [0.35–3.87] | 1.28 [0.29–5.56] | 0.78 [0.10–6.00] |
Pulmonary | – | – | 4.98 [1.50–16.59] |
Central nervous System | 1.12 [0.15–8.29] | – | – |
Hematological | 1.10 [0.50–2.42] | 0.61 [0.22–1.69] | 4.99 [1.58–15.76] |
Biological | 1.35 [0.60–3.06] | 6.57 [1.51–28.55] | 1.68 [0.57–4.95] |