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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Wnt/beta-catenin pathway: modulating anticancer immune response

Fig. 3

Mechanisms of immune exclusion through Wnt/beta-catenin pathway: Activation of Wnt/beta-catenin pathway in tumor leads to noninflammatory milieu through multiple mechanisms. a By acting on Batf3-lineage CD103+ dendritic cells, decreasing CCL4 production by inducing the gene expression of the transcription repressor ATF3. This in turn reduces CD8+ T cell priming and infiltration. b By interacting with tumor-associated macrophages (TAM) through Snail (a soluble factor product of a Wnt-regulated gene) which can in turn increase beta-catenin activity by IL-1β. c β-catenin can enhance Treg survival through unknown mechanisms

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