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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

Fig. 5

Inhibition of human platelet adhesion to collagen by MHCSZ-123 under shear stress. Heparinized whole blood was perfused over the collagen substrate at a constant high (1200 s−1) or low (300 s−1) shear rate at 37 °C for 5 min. The fluorescence microscope images of platelet adhesion at 0, 1, 3, and 5 min of perfusion under high or low shear stress are presented (10 × 20). a MHCSZ-123 inhibited VWF binding to collagen under high shear stress, similar to the parent mAb SZ-123. b Neither MHCSZ-123 nor SZ-123 inhibited VWF binding to collagen under low shear stress. The concentration of antibodies was 10 μg/ml. The non-inhibitory antibody SZ-34 (10 μg/ml) was used as a control

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