Table 2 Comparison between the sepsis patients with and without thrombocytopenia
Variables | Sepsis without thrombocytopenia (n = 134) | Sepsis with thrombocytopenia (n = 127) | P value |
|---|---|---|---|
 Age (year) | 69.5 (54.5, 78.3) | 68 (55.0, 77.0) | 0.468 |
 Male | 91 (67.9) | 84 (66.1) | 0.793 |
 APACHE II | 18.5 (15.3, 23.8) | 20 (10, 24.8) | 0.861 |
  Predicted death rate (%) | 31.5 (21, 45.2) | 37.3 (20.4, 53.5) | 0.217 |
 SOFA | 5 (3.25, 7) | 10 (5, 12) | <0.001 |
 PCT (ng/mL) | 1.55 (0.32, 5.36) | 6.69 (1.0, 38.9) | <0.001 |
 SA (mmol/L) | 732.8 ± 156.5 | 669.1 ± 143.9 | 0.089 |
 MAP (mmHg) | 86.8 ± 15.5 | 79.6 ± 14.7 | <0.001 |
 Heart rate (beat/min) | 93.3 (88.0, 106.3) | 98 (84, 116) | 0.221 |
 White blood cell (×109/L) | 12.5 (8.4, 15.4) | 14.1 (7.81, 15.5) | 0.352 |
 Platelet count (×109/L) | 196.5 (143.5, 299.75) | 45 (33.25, 64.75) | <0.001 |
 BUN (mmol/L) | 7.4 (5.18, 17.3) | 7.51 (4.06, 14.6) | 0.402 |
 Creatinine (μmol/L) | 81 (56.0, 119.0) | 88 (63.3, 225.0) | 0.036 |
 Total bilirubin (μmol/L) | 14.8 (9.9, 23.1) | 18.8 (11.4, 35.0) | 0.098 |
 Albumin (g/L) | 25.5 ± 3.48 | 24.8 ± 5.75 | 0.267 |
Infection pathogens (%) | |||
   Escherichia coli | 12 (8.96) | 25 (19.7) | 0.020 |
   Klebsiella pneumoniae | 22 (16.4) | 11 (8.66) | 0.065 |
   Pseudomonas aeruginosa | 30 (22.4) | 11 (8.66) | 0.030 |
   Acinetobacter baumanii | 13 (9.70) | 7 (5.51) | 0.248 |
   Staphylococcus aureus | 21 (15.7) | 5 (3.93) | 0.020 |
   Streptococcus pneumonae | 1 (0.75) | 2 (1.57) | 0.641 |
   Enterococcus faecium | 5 (3.73) | 4 (3.15) | 0.999 |
 Chicken enterococcus | 1 (0.75) | 2 (1.57) | 0.614 |
  Proteus mirabilis | 0 | 1 (0.78) | 0.487 |
  Candida albicans | 1 (0.75) | 2 (1.57) | 0.614 |
  Aspergillus | 3 (2.24) | 7 (5.51) | 0.207 |
 Viruses | 17 (12.7) | 36 (28.3) | 0.002 |
  New Bunya virus | 0 | 21 (16.5) | <0.001 |
  Influenza A virus subtype H1N1 | 6 (4.48) | 6 (4.72) | 0.999 |
  Others | 11 (10.4) | 9 (9.45) | 0.818 |
Infection sites (%) | |||
  Lung | 69 (51.5) | 29 (22.8) | <0.001 |
  Bloodstream | 8 (5.97) | 33 (23.6) | <0.001 |
  Abdominal cavity | 11 (8.21) | 15 (11.1) | 0.409 |
  Hepatobiliary system | 8 (5.97) | 9 (6.9) | 0.804 |
 Urinary system | 6 (4.48) | 8 (6.9) | 0.589 |
 Surgical incision | 3 (2.24) | 3 (6.9) | 0.632 |
 Skin and soft tissue | 2 (1.49) | 2 (1.4) | 0.668 |
 Central nervous system | 2 (1.49) | 1 (1.4) | 0.520 |
 Others | 25 (18.7) | 27 (21.3) | 0.644 |
Platelet desialylation level (%) | |||
 RCA-I | 90.14 ± 8.88 | 95.64 ± 4.19 | 0.014 |
 ECL | 2.33 ± 1.90 | 5.70 ± 4.37 | <0.001 |
 sWGA | 0.15 ± 0.95 | 0.50 ± 0.293 | <0.001 |
 Mechanical ventilation | 63 (47.0) | 72 (56.7) | 0.137 |
 Renal replacement therapy | 19 (14.2) | 32 (25.2) | 0.029 |
 Septic shock | 11 (8.2) | 24 (18.9) | 0.017 |
 ARDS | 30 (22.4) | 34 (26.8) | 0.472 |
 Bleeding | 32 (23.9) | 29 (22.8) | 0.884 |
 28-day mortality | 19 (14.2) | 46 (36.2) | <0.001 |