Fig. 1
From: The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer
Gαh-OE correlates with the metastatic progression of breast cancer. a A global meta-analysis of the expression of Gαh gene (TGM2) in clinical cohorts with different cancer types using the PrognoScan database. EP denotes endpoint, N indicates patient number, and P represents the statistical significance by Cox regression. b Kaplan-Meier plot for Gαh gene expression from GSE7390, GSE1456, GSE8894, and GSE31210 datasets in the PrognoScan database to evaluate the probability of distant metastasis-free survival (DMSF) or recurrence-free survival (RFS). c Heatmap of Gαh gene expression in normal tissues and metastatic and primary tumor tissues derived from clinical breast cancer patients in TCGA database. d Gαh gene expression in normal tissues and tumor tissues derived from patients with non-TNBC, TNBC, and metastatic breast cancer in TCGA database. e Gαh gene expression in paired normal and tumor tissues derived from breast cancer patients in TCGA database. f and g Kaplan-Meier analysis of Gαh gene levels (f) and Gαh gene transcriptional activity (g) in cohorts with low and high risk of lung metastasis in estrogen receptor (ER)-negative breast cancer patients from the GSE5327 dataset in the SurvExpress database