Fig. 6
From: Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas
Treatment of IB115 (DDLPS) and IB114 (MFH) cells with nutlin and/or a cdk4 inhibitor induces apoptosis. a Cells were incubated with RG-7388 and/or PD0332991, and the annexin V-positive fractions were measured by flow cytometry at 72 h. The results are expressed as the mean ± SEM. b The effects of the single drugs alone and the two-drug combination on the cell cycle were measured by flow cytometry