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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B

Fig. 7

SIX3 expression indicates the sensitivity of astrocytoma cells to aurora kinase inhibitors. a U251-CON and U251-SIX3 cells were treated with a concentration gradient of VX680 for 48 and 72 h and subjected to CCK8 assay. The data represent the mean of five replicates. b U251 and U87 cells were treated with a concentration gradient of VX680 for 48 h and subjected to CCK8 assay. The data represent the mean of five replicates. * U251 vs U118, + U251 vs U87, # U118 vs U87. c Western blotting analysis showed the expression of SIX3, AURKA, and AURKB in normal astrocytes and three primary human patient-derived astrocytomas. d The three primary patient-derived astrocytomas were treated with a concentration gradient of VX680, MLN8237, and AZD1152 for 48 h and subjected to CCK8 assays. * G20151104 vs G20151124B, + G20151104 vs G20151124C, # G20151124B vs G20151124C. The data represent the mean of five replicates (* or + or #, P < 0.05; ** or ++ or ##, P < 0.01; *** or +++ or ###, P < 0.001)

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