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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases

Fig. 2

AD0157 reduces tumor colonization and lymphatic density in draining LNs. a Representative pictures of ex vivo bioluminescent signals recorded in draining LNs at mice sacrifice. The percentage of positive LNs for tumor cells is indicated. b Quantification of bioluminescent radiance in LNs. c Immunostainings of human Ki-67 (proliferative cells in brown, left panels) and LYVE-1 (lymphatic vessels in dark pink, right panels) in whole LN histological sections. Panels at high magnification illustrate the region delineated by the square in the complete LNs. Scale bars represent 250 μm. d Human ki-67+ cell density (surface occupied by tumor cells divided by the total LN surface), lymphatic density (surface occupied by lymphatic vessels divided by the total LN surface), and spatial distributions of tumor cells and lymphatic vessels in LNs. The spatial distribution is calculated from the LN edge, where the distance is equal to 0

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