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Table 1 High Blimp-1 expression on CD4+ T cells associates with increased blast in AML

From: Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Total

High-Blimp-1

Low-Blimp-1

P value

(n = 24)

(n = 13)

(n = 11)

 

Age, years

 Median

61

59

0.797

 Range

23–75

24–77

 

Gender

 Male

6

4

0.628

 Female

7

7

 

WBC, × 109/l

 Median

82.9

24.9

0.033

 Range

5.8–364.6

5.1–87

 

PB blast, %

 Median

68

73

0.721

 Range

1.9–93.8

18–90.8

 

Absolute blast counts, × 109/l

 Median

41

16

0.026

 Range

0.1–342

3–47

 

BM blast, %

 Median

60

64.5

0.626

 Range

1.5–88

34.5–79

 

Cytogeneticsa

 Adverse

6

6

0.799

 Intermediate

5

4

 

 Favorable

1

1

 
  1. WBC white blood cell, ANC absolute neutrophil counts, PB peripheral blood, BM bone marrow, ITD internal tandem duplication.
  2. aRisk stratification is based on the 2017 European Leukemia Net Recommendations. Clinical information for risk stratification was not available for one patient, thus data of 23 (12 of high Blimp-1, 11 of low Blimp-1) are shown