Fig. 2

Schematic illustration of miRNA regulation by epigenetic modifiers in MM. Epigenetic modifications such as DNA methylation, histone methylation and histone deacetylation suppress tumor suppressor miRNAs. The miRNAs target downstream genes that are involved in different cell processes such as cell proliferation, apoptosis and DNA repair. Suppression of miRNAs by epigenetic dysregulation leads to overexpression of these target genes which determine the phenotype of DR in MM