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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: RETRACTED ARTICLE: MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway

Fig. 3

Over-expression of miR-330-3p induces the ability of tube formation, migration, and invasion in NSCLC cells. a Tube formation assay measuring proangiogenic activity in H460 and H1975 cells; tube formation was assessed using an inverted light microscope (Olympus IX71, original magnification ×100). b Wound-healing assays were performed to assess NSCLC cell migration. Wound closure was determined 24 h after the scratch. c Transwell migration assay measuring NSCLC cell migration in H460 and H1975 cells stably transfected with NC-LV, OE-miR-330-3p-LV or anti-miR-330-3p-LV, respectively. The number of migrated cells was evaluated by counting 10 random fields at ×100 magnification. d Transwell invasion assay was used to quantify cell invasion in a Matrigel-coated chamber. The average number of cells invading per field of view in three different experiments is plotted. Error bars indicate mean ± SD, a representative experiment of three was reported. *P < 0.05, **P < 0.01, #P < 0.001, one-way ANOVA

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