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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

Fig. 1

EDO-S101 inhibits the viability of MM cell lines and primary MM cells even in the presence of the microenvironment. Seven MM cell lines were incubated with different concentrations of (a) EDO-S101 and (b) bendamustine for 48 h. Cell viability was analyzed by MTT reduction. c EDO-S101 efficacy was investigated ex vivo on BM samples from six patients with MM. d MM1S cells were treated for 48 h with the indicated concentrations of EDO-S101 in the presence or absence of IL-6 (1 nM) or IGF-1 (10 nM). e MM1.S-luc cells treated with EDO-S101 in the presence or absence of BMSCs from patients with MM. Cell viability of MM1S-luc cells was analyzed by luminescence, reported in relative light units (RLU), and normalized to that of MM1S-luc cells in monoculture in absence of the drug. Data are expressed as mean ± SD of three independent experiments

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