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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation

Fig. 5

CD40+ MC is a reliable biomarker for CKD severity. CD40+ MC and plasma sCD40L were examined in human CKD subjects (experimental details in Yang et al. [15]). Peripheral WBC were isolated after red blood cell lysis and stained with antibodies against CD14, CD16, and CD40 for flow cytometry analysis. a CD40+ MC. CD40+ MC subset was elevated in patients with CVD and CVD+CKD compared to healthy subjects and increased with CKD severity. b Plasma sCD40L. sCD40L was elevated in patients with CVD and CVD+CKD compared to healthy subjects. c CD40+ intermediate MC. CD40+ intermediated MC subset was elevated in patients with CVD and CVD+CKD compared to healthy subjects and increased with CKD severity. d Intermediate MC. Intermediate MC subset was elevated in CVD patients, but not further increased in CVD+CKD patients. *p < 0.05 vs healthy. Abbreviations: CKD chronic kidney disease, CVD cardiovascular disease, MC monocyte, PBMC peripheral blood mononuclear cells, sCD40L soluble CD40 ligand, WBC white blood cells

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