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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model

Fig. 1

Generation of the Asxl1 G643WfsX12 knock-in mice. a Schematic illustration of the generation strategies of the knock-in mouse model. b DNA sequences of Asxl1 G643WfsX12 heterozygous, homozygous and wild-type bone marrow cells. Asxl1 mutant had an additional guanine inserting into the 8-G cassette leading to Asxl1 G643WfsX12 mutation. Since cells with heterozygous Asxl1 mutant had both 8-G wild-type and 9-G mutant alleles, there were overlapping signals caused by 9-G mediated frame shift after the 8-G/9-G cassette

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