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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

Fig. 2

RNAi-mediated depletion of TEP1 recapitulates the biological effects of miR-380-5p. a TEP1 mRNA expression levels (upper panel) and protein amounts (lower panel) in STO cells assessed 72 h after the transfection with the indicated siRNAs. Data have been reported as RQ (mean values ± s.d.) in siCTR and siTEP1-transfected vs. NT cells; ***P < 0.001 vs. siCTR-transfected cells. b Relative TA in siCTR and siTEP1-transfected STO vs. NT cells (mean values ± s.d.); ***P < 0.001 vs. siCTR-transfected cells. c STO cell growth assessed 72 h after siRNA-mediated depletion of TEP1 (number of growing NT, siCTR- and siTEP1-transfected cells; mean values ± s.d.); **P < 0.01 vs. siCTR-transfected cells

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Journal of Hematology & Oncology

ISSN: 1756-8722

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