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Table 1 Summary of ALL samples included in the study

From: Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles

Immuno-phenotype

Cytogenetic abnormality

Fusion gene

N

Median WBC at diagnosis, × 10^9/L (range)

Median age at diagnosis, years (range)

T-ALL

Various

 

18

173.5 (1–588)

11.9 (1.9–16.8)

BCP-ALL

HeH

42

9.6 (0.8–124)

3.6 (1.0–17.74

 

t(12;21)

ETV6-RUNX1

18

6.5 (1.1–95)

4.9 (2.2–12.7)

 

11q23/MLL

MLL-r

7

193 (1.8–744)

0.6 (0.5–1.7)

 

t(9;22)

BCR-ABL1

6

88.3 (14.1–180)

12.1 (9.3–13.5)

 

dic(9;20)

1

41.8 (41.8–41.8)

4.4 (4.4–4.4)

 

Various (BCP-ALL “other”)a

42

7.9 (0–213)

8.8 (1.4–17.7)

Total

  

134

  
  1. aBCP-ALL samples negative for targeted assays for known ALL cytogenetic aberrations with either non-recurrent aberrations, normal karyotypes, or no results available from cytogenetic analysis
  2. WBC white blood cell count at diagnosis, MLL-r rearrangements involving the KMT2A (MLL) gene