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Table 2 Common side effects of different immunotherapies

From: Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia

Targets Medications Side effects
CD20 Rituximab Most common side effect is mild to moderate infusion reactions. Rare cases of severe mucocutaneous reactions, HBV reactivation, and progressive multifocal leukoencephalopathy
Ofatumumab Primarily grade 1 or 2 infusion reactions or infections
CD19 SAR3419 Dose-limiting reversible severe vision changes associated with corneal changes
SGN-CD19A Superficial microcystic keratopathy
Blinatumomab Fever, chills, and hypogammaglobulinemia are common. Serious side effects include CRS and neurotoxicity
CD22 Epratuzumab Seizure, liver toxicity
INO Liver toxicity, veno-occlusive disease in transplant patients
CD52 Alemtuzumab Severe neutropenia, CMV viremia