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Table 1 Demographic characteristics of 322 patients enrolled in two prospective registries and correlation with GEP Class

From: Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test

  All cases (n* = 322) Class 1 (n = 248) Class 2 (n = 74) p value***
Age, median (range) 58 (18–87) 57 (18–87) 65 (23–85) 0.003
 Gender
  Female 146 (45%)** 123 (50%) 23 (31%) 0.005
  Male 176 (55%) 125 (50%) 51 (69%)  
Breslow thickness, median (range) 1.2 (0.2–12.0) 1.0 (0.2–7.0) 2.5 (0.4–12.0) <0.001
 Ulceration
  Absent 238 (74%) 204 (82%) 34 (46%) <0.001
  Present 58 (18%) 23 (9%) 35 (47%)  
  Unknown 26 (8%) 21 (9%) 5 (7%)  
 Mitotic rate
   ≤1/mm2 222 (69%) 176 (71%) 46 (62%) 0.151
   >1/mm2 100 (31%) 72 (29%) 28 (38%)  
 Node status
  Negative 286 (89%) 228 (92%) 58 (78%) 0.007
  Positive 36 (11%) 20 (8%) 16 (22%)  
 Primary tumor location
  Extremity 178 (55%) 133 (54%) 45 (61%) 0.547
  Head and neck 58 (18%) 46 (19%) 12 (16%)  
  Trunk 86 (27%) 69 (28%) 17 (23%)  
 AJCC stage
  None 3 (1%) 3 (1%) 0 (0%) <0.001
  I 1 (0%) 1 (0%) 0 (0%)  
  IA 63 (20%) 62 (25%) 1 (1%)  
  IB 145 (45%) 129 (52%) 16 (22%)  
  IIA 39 (12%) 23 (9%) 16 (22%)  
  IIB 26 (8%) 9 (4%) 17 (23%)  
  IIC 8 (2%) 0 (0%) 8 (11%)  
  III 30 (9%) 16 (6%) 14 (19%)  
  IIIA 3 (1%) 3 (1%) 0 (0%)  
  IIIB 3 (1%) 1 (0%) 2 (3%)  
  IV 1 (0%) 1 (0%) 0 (0%)  
 Location of first recurrence
  Nodal/regional 13 3 10 0.69
  Distant 12 2 10  
  1. *n = number of samples
  2. **All percentages are reflective of the indicated group out of the total number of samples in that column
  3. ***p values reflect differences between class 1 and 2 patients and were calculated using chi-squared or F tests as appropriate