| |
All cases (n* = 322)
|
Class 1 (n = 248)
|
Class 2 (n = 74)
|
p value***
|
|---|
|
Age, median (range)
|
58 (18–87)
|
57 (18–87)
|
65 (23–85)
|
0.003
|
|
Gender
|
|
Female
|
146 (45%)**
|
123 (50%)
|
23 (31%)
|
0.005
|
|
Male
|
176 (55%)
|
125 (50%)
|
51 (69%)
| |
|
Breslow thickness, median (range)
|
1.2 (0.2–12.0)
|
1.0 (0.2–7.0)
|
2.5 (0.4–12.0)
|
<0.001
|
|
Ulceration
|
|
Absent
|
238 (74%)
|
204 (82%)
|
34 (46%)
|
<0.001
|
|
Present
|
58 (18%)
|
23 (9%)
|
35 (47%)
| |
|
Unknown
|
26 (8%)
|
21 (9%)
|
5 (7%)
| |
|
Mitotic rate
|
|
≤1/mm2
|
222 (69%)
|
176 (71%)
|
46 (62%)
|
0.151
|
|
>1/mm2
|
100 (31%)
|
72 (29%)
|
28 (38%)
| |
|
Node status
|
|
Negative
|
286 (89%)
|
228 (92%)
|
58 (78%)
|
0.007
|
|
Positive
|
36 (11%)
|
20 (8%)
|
16 (22%)
| |
|
Primary tumor location
|
|
Extremity
|
178 (55%)
|
133 (54%)
|
45 (61%)
|
0.547
|
|
Head and neck
|
58 (18%)
|
46 (19%)
|
12 (16%)
| |
|
Trunk
|
86 (27%)
|
69 (28%)
|
17 (23%)
| |
|
AJCC stage
|
|
None
|
3 (1%)
|
3 (1%)
|
0 (0%)
|
<0.001
|
|
I
|
1 (0%)
|
1 (0%)
|
0 (0%)
| |
|
IA
|
63 (20%)
|
62 (25%)
|
1 (1%)
| |
|
IB
|
145 (45%)
|
129 (52%)
|
16 (22%)
| |
|
IIA
|
39 (12%)
|
23 (9%)
|
16 (22%)
| |
|
IIB
|
26 (8%)
|
9 (4%)
|
17 (23%)
| |
|
IIC
|
8 (2%)
|
0 (0%)
|
8 (11%)
| |
|
III
|
30 (9%)
|
16 (6%)
|
14 (19%)
| |
|
IIIA
|
3 (1%)
|
3 (1%)
|
0 (0%)
| |
|
IIIB
|
3 (1%)
|
1 (0%)
|
2 (3%)
| |
|
IV
|
1 (0%)
|
1 (0%)
|
0 (0%)
| |
|
Location of first recurrence
|
|
Nodal/regional
|
13
|
3
|
10
|
0.69
|
|
Distant
|
12
|
2
|
10
| |
- *n = number of samples
- **All percentages are reflective of the indicated group out of the total number of samples in that column
- ***p values reflect differences between class 1 and 2 patients and were calculated using chi-squared or F tests as appropriate
