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Table 1 Demographic characteristics of 322 patients enrolled in two prospective registries and correlation with GEP Class

From: Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test

 

All cases (n* = 322)

Class 1 (n = 248)

Class 2 (n = 74)

p value***

Age, median (range)

58 (18–87)

57 (18–87)

65 (23–85)

0.003

 Gender

  Female

146 (45%)**

123 (50%)

23 (31%)

0.005

  Male

176 (55%)

125 (50%)

51 (69%)

 

Breslow thickness, median (range)

1.2 (0.2–12.0)

1.0 (0.2–7.0)

2.5 (0.4–12.0)

<0.001

 Ulceration

  Absent

238 (74%)

204 (82%)

34 (46%)

<0.001

  Present

58 (18%)

23 (9%)

35 (47%)

 

  Unknown

26 (8%)

21 (9%)

5 (7%)

 

 Mitotic rate

   ≤1/mm2

222 (69%)

176 (71%)

46 (62%)

0.151

   >1/mm2

100 (31%)

72 (29%)

28 (38%)

 

 Node status

  Negative

286 (89%)

228 (92%)

58 (78%)

0.007

  Positive

36 (11%)

20 (8%)

16 (22%)

 

 Primary tumor location

  Extremity

178 (55%)

133 (54%)

45 (61%)

0.547

  Head and neck

58 (18%)

46 (19%)

12 (16%)

 

  Trunk

86 (27%)

69 (28%)

17 (23%)

 

 AJCC stage

  None

3 (1%)

3 (1%)

0 (0%)

<0.001

  I

1 (0%)

1 (0%)

0 (0%)

 

  IA

63 (20%)

62 (25%)

1 (1%)

 

  IB

145 (45%)

129 (52%)

16 (22%)

 

  IIA

39 (12%)

23 (9%)

16 (22%)

 

  IIB

26 (8%)

9 (4%)

17 (23%)

 

  IIC

8 (2%)

0 (0%)

8 (11%)

 

  III

30 (9%)

16 (6%)

14 (19%)

 

  IIIA

3 (1%)

3 (1%)

0 (0%)

 

  IIIB

3 (1%)

1 (0%)

2 (3%)

 

  IV

1 (0%)

1 (0%)

0 (0%)

 

 Location of first recurrence

  Nodal/regional

13

3

10

0.69

  Distant

12

2

10

 
  1. *n = number of samples
  2. **All percentages are reflective of the indicated group out of the total number of samples in that column
  3. ***p values reflect differences between class 1 and 2 patients and were calculated using chi-squared or F tests as appropriate