Fig. 2
From: Association of a novel point mutation in MSH2 gene with familial multiple primary cancers
Germline mutation and inactivation of MSH2 in a family with Lynch syndrome. a Identification of a causal germline mutation in MSH2 from whole genome sequencing. b Validation of MSH2 mutation in affected and unaffected members. All affected individuals have an rs267607964 variant, while unaffected individuals do not have such mutation. c The detection of MSH2 expression in protein levels in cancer tissues