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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Association of a novel point mutation in MSH2 gene with familial multiple primary cancers

Fig. 4

Comparison of altered genes and pathways in different cancer tissues of a patient with Lynch syndrome. a Venn diagram showing the overlapping sites or genes in RPC and SIC. b Number of altered genes in 13 cancer-related pathways. Orange represents genes with recurrent mutations in TCGA Pan-Cancer Project and blue indicates other genes. c Summary of point mutations in 22 genes across 2 cancers from patient III4 and 8 cancer types of TCGA. These 22 genes are mutated in RPC or SIC, and they were reported as significantly mutated genes by TCGA Pan-Cancer analysis

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