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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Association of a novel point mutation in MSH2 gene with familial multiple primary cancers

Fig. 5

MH2 mutations and its effects in inherited and non-inherited cancers. a Proposed model for the mutagenic progress of MPC in Lynch syndrome. b Proposed model for the mutagenic progress of non-inherited cancers. c MSH2 diagram of the germline variants in inherited cancer syndromes or somatic mutations in TCGA Pan-Cancer. Germline variants were collected from the previous reported pathologic variants in ClinVar database. The mutation found in the present study is highlighted by the asterisk. Red color illustrates truncating mutations (nonsense, nonstop, splicing, frameshift, and indels)

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