Fig. 3

Oxygen sensors, VEGF pathway regulators, and stem cell master regulators may regulate nuclear receptor expression in human tissues (tissues: adipose, brain, eye, heart, kidney, liver, lymph node, muscle, pancreas, skin, spleen). a Highly expressed nuclear receptors in 11 tissues were strongly associated with angiogenic gene expression. b Correlation between highly expressed nuclear receptors and gene that regulate oxygen sensing, angiogenesis, and stem cells. c Correlation tiers between genes of interests and nuclear receptor expression in tissues. Abbreviations: PHD2: prolyl hydroxylase domain-containing protein 2; HIF1B: hypoxia-inducible factor-1 beta; HIF1/2A: hypoxia-inducible factor 1/2-alpha; VEGFA/B/C: vascular endothelial growth factor A/B/C; FIGF: C-fos-induced growth factor; FLT1/4: Fms related tyrosine kinase ¼; KDR: kinase insert domain receptor; MYC: MYC proto-oncogene; KIT: KIT proto-oncogene receptor tyrosine kinase; KLF4: Kruppel-like factor 4; POU5F1: POU class 5 homeobox 1; SOX2: SRY-box 2